Andrographolide

ʻO Andrographolide kahi hua huaʻai i lawe ʻia mai kahi lāʻau i kū maoli ma Kina.He moʻolelo nui ko ka lau nahele o ka hoʻohana ʻana ma TCM no ka mālama ʻana i nā maʻi ʻeha o ka ʻōpū o luna a me nā maʻi ʻeha a me nā maʻi lele.Ua hoʻolauna ʻia a mahi ʻia ʻo Andrographis paniculata ma Guangdong a me Fujian hema i ka makahiki 50.Hoʻohana ʻia ia e mālama i nā ʻano maʻi lele a me nā nahu nahesa.I nā makahiki i hala iho nei, ua aʻo ʻia ka mahiʻai, ka hoʻohui kemika, ka lāʻau lapaʻau a me nā ʻano lapaʻau o Andrographis paniculata ma Kina.ʻO Andrographis paniculata kahi lāʻau lapaʻau Kina maʻamau, nona ka hopena o ka hoʻomaʻemaʻe ʻana i ka wela a me nā mea ʻawaʻawa, hoʻomaʻalili koko a me ka detumescence.ʻO ka maʻi maʻi, hoʻohana nui ʻia no ka mālama ʻana i ka maʻi ʻeha hanu, ka maʻi maʻi bacillary acute, gastroenteritis, ke anu, ke kuni a me ka hypertension.Me ka hoʻonui ʻana o ka hoʻohana ʻana i nā lāʻau antibiotic a me nā hopena ʻino, ke ulu nei ka leo o ka hoʻomohala ʻana i ka lāʻau lapaʻau Kina me ka hopena antibacterial maikaʻi.ʻO Andrographis paniculata, he lāʻau lapaʻau Kina kuʻuna me ka hopena antibacterial, ua uku nui ʻia e ka ʻoihana lāʻau.

ʻIke ʻia ka lāʻau lāʻau Andrographis paniculata e loaʻa i nā ʻano hana lāʻau lapaʻau.ʻO Andrographolide, ka mea nui o ka extract e pili ana i kāna hana pharmacological.Ua aʻo mākou i nā kaʻina kelepona a me nā pahuhopu i hoʻololi ʻia e ka lāʻau andrographolide i ka maʻi maʻi kanaka a me nā cell immune.Ua kāohi ka lāʻau Andrographolide i ka hoʻonui in vitro o nā laina cell tumor like ʻole, e hōʻike ana i nā ʻano maʻi maʻi like ʻole.Hoʻohana ka pūhui i ka hana anticancer ma luna o nā pūnaewele maʻi maʻi ma o ka hopu ʻana i ka pōʻaiapili cell ma ka pae G0/G1 ma o ka hoʻokomo ʻana i ka protein inhibitory cell-cycle p27 a me ka hoʻohaʻahaʻa ʻana o ka cyclin-dependent kinase 4 (CDK4).Hōʻike ʻia ka hana immunostimulatory o andrographolide e ka hoʻonui ʻana o nā lymphocytes a me ka hana ʻana o interleukin-2.Hoʻonui pū ʻo Andrographolide i ka hana ʻana o ka tumor necrosis factor-alpha production a me ka hōʻike hōʻailona CD, ka hopena o ka hoʻonui ʻana i ka hana cytotoxic o nā lymphocytes e kūʻē i nā maʻi maʻi maʻi, hiki ke kōkua i kāna hana anticancer indirect.Hoʻokumu hou ʻia ka hana anticancer in vivo o ka pūhui e kūʻē i ka B16F0 melanoma syngenic a me HT-29 xenograft models.Hōʻike kēia mau hopena i ka andrographolide he pharmacophore hoihoi me nā hana anticancer a me ka immunomodulatory a no laila hiki ke hoʻomohala ʻia ma ke ʻano he lāʻau lapaʻau maʻi kanesa.


Ka manawa hoʻouna: Iune-22-2021